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New Cubano Flower. French Royale, Head Mount, Dark N Stormy, Grape Marvel. While Supplies last. See Root 66 Stores for more details.

Exclusive Discounts Available! Veterans, Industry Workers, Early Birds, & Seniors 60+ – Ask Us!

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Enjoy 10% Off on Medical Tuesdays

Unlock a 10% discount every Tuesday for all medical patients. Elevate your Root 66 experience with exclusive savings on premium products.

Optimize Your Experience: Root 66 Fast Lane – Pre-order Online for Expedited Checkout!

Fast Lane promotion: Pre-order online for a quicker checkout experience at Root 66 Dispensary.

Cubano Extracts – Always in Stock

Explore the unique and potent Cubano strain, always available at Root 66 Dispensary. Find the perfect balance of flavor and effects with Cubano.

Discover OSTARA Cannabis at Root 66

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Apply for Opportunities at Root 66

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LOCATIONS

DES PERES

12095 Manchester Rd.
Des Peres, MO 63131
8 AM - 8 PM

DOGTOWN

6660 Manchester Ave.
St. Louis, MO 63139
8 AM - 10 PM

SOUTH GRAND

3737 S. Grand Blvd.
St. Louis, MO 63118
8 AM - 10 PM

ST. PETERS

3004 S. St. Peters Pkwy
St. Charles, MO 63303
8 AM - 11 PM

WENTZVILLE

1163 Wentzville Pkwy
Wentzville, MO 63385
8 AM - 10 PM

 

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Download
The Root 66 Mobile App today!

Easily track your Highway Miles earned with every purchase, shop your favorite store, place a pre-order, rate and review past purchases, and stay updated on exclusive deals—all from the convenience of your phone.

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