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Dogtown Drive Thru

Dogtown location drive thru now open till 12am.  Pre-orders only.

Cubano Extracts – Always in Stock

Cubano Cannabis logo centered in a frame with buds growing on each side. Text states Always available at Root 66.

Memorial Day Weekend Sale

Root 66 Dispensary Memorial Day Weekend Sale – 25% off Amaze and Sinse Cannabis products, Cubano prerolls priced at $4.99 for 0.5g and $9.99 for 1g. Valid May 23–26, 2025. While supplies last. Discounts cannot be combined with other offers or promotions.

Missouri Owned Grown Rooted

The St Louis arch and riverway in the background with a bright blue sky and summer green foliage. Overlayed with text saying Missouri Owned, Grown, Rooted.

Enjoy 10% Off on Medical Tuesdays

Unlock a 10% discount every Tuesday for all medical patients. Elevate your Root 66 experience with exclusive savings on premium products.

Discover OSTARA Cannabis at Root 66

Promotional banner stating Ostara Cannabis is consistently stocked and available at Root 66.

Rest Gummies

The right side shows a table with lavender flowers in a vase, a lamp, lit small candle, and a package of Ostara Rest gummies. The left side has a purple background with Ostara Cannabis logo at the top, then states, Tired of counting sheep? Ask about Rest Gummies. Below are outlines of sheep jumping over a fence, drawn in light purple.

Apply for Opportunities at Root 66

Banner announcing job applications are now open. Visit the jobs tab to apply and join our team.

Root 66 St. Peters 24/7

Root 66 St. Peters now open 24/7 with a Walk-up Window.  3004 S. St. Peters Pkwy, St. Charles, MO 63303

Displayed on a background, half green and half red brick with a walkup window built into it.  Root 66 Dispensary logo centered at the top of the image.

Exclusive Discounts Available! Veterans, Industry Workers, Early Birds, & Seniors 60+ – Ask Us!

Banner encouraging customers to inquire about available discounts for Veterans, Industry Workers, Early Birds, and Seniors 60+.

Ostara bundle deals

Ostara Cannabis and Root 66 logos on a pot field background. Buy More Save More! .5g vape cart $23.99, 2 for $44.99, 3 for $64.99. 1g vape cart $39.99, 2 for $74.99, 3 for $99.99. 100mg OG gummies $9.99. 200mg Gummies $21.99, 2 for $39.99. 750mg gummies $64.99, 2 for $166.99. Live resin, Rise, Rest, and Balance gummies $19.99, 2 for $34.99. Star Tabs $34.99, 2 for $64.99. Galaxy Tabs $14.99, 2 for $26.99. 1g disposable $44.99, 2 for $84.99, 3 for $199.99. Can’t be combined with other offers or discounts, While Supplies Last.

Ostara On The Go $3.99

Green background with Ostara On The Go written. Featuring a 2 pack of mystery flavor gummies in a blue package appearing to burst from multi colored fluid. These two packs are $3.99.

Optimize Your Experience: Root 66 Fast Lane – Pre-order Online for Expedited Checkout!

Fast Lane promotion: Pre-order online for a quicker checkout experience at Root 66 Dispensary.

LOCATIONS

DES PERES

12095 Manchester Rd.
Des Peres, MO 63131
8 AM - 10 PM
 
 

DOGTOWN

6660 Manchester Ave.
St. Louis, MO 63139
8 AM - 10 PM
(Drive-Thru: 8 AM - 12 AM)
 

SOUTH GRAND

3737 S. Grand Blvd.
St. Louis, MO 63118
8 AM - 10 PM
 
 

ST. PETERS

3004 S. St. Peters Pkwy
St. Peters, MO 63303
24/7
(walk-up window 12AM-7:59AM)
 

WENTZVILLE

1163 Wentzville Pkwy
Wentzville, MO 63385
8 AM - 10 PM
 
 

 

Root 66 Road Crew Rewards logo in tan on a green background

Get Rewards, New Product Alerts, Flash Sales and More!

Get Your
Missouri Medical Marijuana
Card Online Now at

Apply for a Missouri Medical Marijuana Card with NuggMD

For Assistance Click Here

Get Your
Missouri Medical Marijuana
Card Online Now

Apply for a Missouri Medical Marijuana Card with NuggMD

For assistance Click Here

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The Root 66 Mobile App today!

Easily track your Highway Miles earned with every purchase, shop your favorite store, place a pre-order, rate and review past purchases, and stay updated on exclusive deals—all from the convenience of your phone.

Smartphones displaying the Root 66 mobile app.

Download
The Root 66 Mobile App today!

Easily track your Highway Miles earned with every purchase, shop your favorite store,
place a pre-order, rate and review past purchases, and stay updated on exclusive deals—
all from the convenience of your phone.

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