DES PERES
12095 Manchester Rd.
Des Peres, MO 63131
Open Everyday 8 AM - 10 PM
About Des Peres Root 66
Welcome to our newest Root 66 location at 12095 Manchester in Des Peres, MO 63131! We are thrilled to have become a part of this vibrant and beautiful city since our grand opening in September 2023. Nestled in a convenient spot, our Des Peres location is strategically placed to provide you with easy access to our wide range of products. The city's charm and welcoming atmosphere make it an ideal setting for a Root 66 store, and we are excited to be a part of the community.
At Root 66 Des Peres, our dedicated team is here to serve you and ensure you have the best experience possible. Feel free to explore our product offerings, and don't hesitate to approach our knowledgeable budtenders with any questions you may have. We are committed to providing excellent customer service and assisting you in finding the perfect products to meet your needs. We look forward to being your go-to destination for all things Root 66 in Des Peres!
Find us at Root 66 Dispensary Des Peres, located at 12095 Manchester Rd, Des Peres, MO 63131. Click here for directions.
Our Store Manager’s
Top Picks
Meet Christian Isringhaus, the welcoming face behind our Des Peres location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Christian has some standout recommendations for you.
“I am a firm believer in the benefits of consuming cannabis. It has improved my quality of life by helping manage stress, anxiety, and depression, while opening my mind to new possibilities and experiences. I have seen it help people from all walks of life, from veterans struggling with depression to the elderly mailman whose knees ache from arthritis. The Root 66 team is devoted to serving the people of St. Louis, and we are ready and excited to help everyone along their cannabis journey.”
Christian Isringhaus
Favorite Consumption Method:
Concentrates. I prefer live rosin or live resin.
Must-Try Strain:
If you ever have the chance to try Banana OG do not pass it up! That strain melts stress away like no other. Good for a relaxing night on the couch or before bed to sleep.
When did you start working for Root 66?
February 2026. With nearly a decade of retail cannabis experience in Colorado and Missouri, I decided I wanted to work for Root 66 because they are a St Louis owned and operated company that cares deeply about this city.
Grow with Us
Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.
Google Reviews
Trustindex verifies that the original source of the review is Google. This was my first visit to this dispensary. Cedric helped me and he was a delight…the entire staff was very friendly and welcoming, including the guard. I also love that they have a pet food donation box. This will definitely be my favorite place.Trustindex verifies that the original source of the review is Google. Always good energy when I come in. Good stock, great prices.Trustindex verifies that the original source of the review is Google. Always super fast and friendly, great selection! Mimi was super helpful as well :)Trustindex verifies that the original source of the review is Google. My favorite store in the world! Employees are happy and helpful. I love the wide range of options and something for every price range.Trustindex verifies that the original source of the review is Google. Katie was awesome and super helpful! It's a great place!
