About Des Peres Root 66

Welcome to our newest Root 66 location at 12095 Manchester in Des Peres, MO 63131! We are thrilled to have become a part of this vibrant and beautiful city since our grand opening in September 2023. Nestled in a convenient spot, our Des Peres location is strategically placed to provide you with easy access to our wide range of products. The city's charm and welcoming atmosphere make it an ideal setting for a Root 66 store, and we are excited to be a part of the community.

At Root 66 Des Peres, our dedicated team is here to serve you and ensure you have the best experience possible. Feel free to explore our product offerings, and don't hesitate to approach our knowledgeable budtenders with any questions you may have. We are committed to providing excellent customer service and assisting you in finding the perfect products to meet your needs. We look forward to being your go-to destination for all things Root 66 in Des Peres!

Our Store Manager’s

Top Picks

Meet Nick Boggs, the welcoming face behind our Des Peres location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Nick has some standout recommendations for you.

“I have been with Root 66 for 3 years now. I have a passion for concentrates, particularly favoring the exquisite world of rosin. I entered this industry to be a part of a movement that goes beyond consumption- It's about fostering well-being and connection. Cannabis has the potential to elevate lives, and I’m proud to contribute to that journey at Root 66.”


Nick Boggs

Favorite Consumption Method:

Rosin Concentrates

Must-Try Strain:

Chocolope. It offers notes of fruit and cake while delivering well-rounded effects.

When did you start working for Root 66?


Nick Boggs - Des Peres Store Manager

Grow with Us

Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.

Google Reviews

Rebel 420
Rebel 420
This was my first visit to this dispensary. Cedric helped me and he was a delight…the entire staff was very friendly and welcoming, including the guard. I also love that they have a pet food donation box. This will definitely be my favorite place.
Josh Marshall
Josh Marshall
Always good energy when I come in. Good stock, great prices.
Jason Koch
Jason Koch
Always super fast and friendly, great selection! Mimi was super helpful as well :)
Jenn W
Jenn W
My favorite store in the world! Employees are happy and helpful. I love the wide range of options and something for every price range.
Charles Jackson
Charles Jackson
Katie was awesome and super helpful! It's a great place!

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