About Des Peres Root 66

IT’S OFFICIAL! We have the green light. We're thrilled to announce the grand opening of our fifth store location tomorrow on Wednesday, September 27th! You can find us at 12095 Manchester, Des Peres, MO 63131. This exciting addition to our family of stores promises to be a hub of convenience and quality. We can't wait to welcome you to our newest location and share in the excitement of this momentous day! See you there!

Our Store Manager’s

Top Picks

Meet Nick Boggs, the welcoming face behind our Des Peres location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Nick has some standout recommendations for you.

“I have been with Root 66 for 3 years now. I have a passion for concentrates, particularly favoring the exquisite world of rosin. I entered this industry to be a part of a movement that goes beyond consumption- It's about fostering well-being and connection. Cannabis has the potential to elevate lives, and I’m proud to contribute to that journey at Root 66.”


Nick Boggs

Favorite Consumption Method:

Rosin Concentrates

Must-Try Strain:

Chocolope. It offers notes of fruit and cake while delivering well-rounded effects.

When did you start working for Root 66?


Nick Boggs Des Peres Store Manager Headshot

Grow with Us

Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.

Google Reviews

Rebel 420
Rebel 420
This was my first visit to this dispensary. Cedric helped me and he was a delight…the entire staff was very friendly and welcoming, including the guard. I also love that they have a pet food donation box. This will definitely be my favorite place.
Josh Marshall
Josh Marshall
Always good energy when I come in. Good stock, great prices.
Jason Koch
Jason Koch
Always super fast and friendly, great selection! Mimi was super helpful as well 🙂
Jenn W
Jenn W
My favorite store in the world! Employees are happy and helpful. I love the wide range of options and something for every price range.
Charles Jackson
Charles Jackson
Katie was awesome and super helpful! It's a great place!

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