View of the store's front entrance from the parking lot, featuring designated accessible parking spaces marked with blue signs and a wheelchair symbol.
Brick building with a grassy lawn and young trees, viewed from the street.
A wider shot showing more of the store's front entrance and landscape.
The store entrance with accessible parking spaces in the foreground, marked with blue signs and painted pavement indicators.
A closer view of the entrance, showing a blue "Reserved Parking" sign with a wheelchair symbol, indicating an accessible parking space.
A spacious store interior featuring glass display cases, a digital menu on a brick wall, a large Route 66 logo sign, and shelving.
A similar view of the counter from a different angle, also showing an ATM on the opposite wall.
A view from the service counter looking towards the store entrance.
A broad view of the store interior with a customer at the counter, highlighting the open layout and service area.
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About Wentzville Root 66

Our Wentzville Root 66 store is located in the fastest growing city in the state of Missouri. Serving an increasing population of 45,000+, this 4,200 square foot location is among the best in Missouri. Wentzville is recognized as host of the annual St. Charles County Fair and the St. Louis Renaissance Festival. Wentzville is the location of the first Vietnam Veterans Memorial in the U.S.

Root 66 is honored to join the Wentzville community and offer local patients a wide variety of cannabis products including: cannabis flower, vapes, concentrates, edibles, beverages and more! We pride ourselves on our commitment to St. Charles County to offer the best experience and widest selection in town.

Find us at Root 66 Dispensary Wentzville, located at 1163 Wentzville Parkway, Wentzville, MO 63385. Click here for directions.

Our Store Manager’s

Top Picks

Meet Kayla Nettles, the welcoming face behind our Wentzville location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Kayla has some standout recommendations for you.

“Cannabis has become a way to relieve my chronic migraines and body aches with a more natural approach. Increasing my knowledge of the medicinal benefits of cannabis and sharing that knowledge with patients has become a true passion. It's time for the stigma around cannabis to change and that change starts here, with us!”

Kayla Nettles

Favorite Consumption Method:

Flower and vape

Must-Try Strain:

Illicit Animal Star Cookies and Ostara Balance Gummies

When did you start working for Root 66?

October 2023

Portrait of Kayla Nettles, store manager at Root 66 Dispensary Wentzville. She has long, wavy green-highlighted hair. A cannabis leaf is in the bottom corner of the image.

Grow with Us

Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.

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