View of the store's front entrance from the parking lot, featuring designated accessible parking spaces marked with blue signs and a wheelchair symbol.
Brick building with a grassy lawn and young trees, viewed from the street.
A wider shot showing more of the store's front entrance and landscape.
The store entrance with accessible parking spaces in the foreground, marked with blue signs and painted pavement indicators.
A closer view of the entrance, showing a blue "Reserved Parking" sign with a wheelchair symbol, indicating an accessible parking space.
A spacious store interior featuring glass display cases, a digital menu on a brick wall, a large Route 66 logo sign, and shelving.
A similar view of the counter from a different angle, also showing an ATM on the opposite wall.
A view from the service counter looking towards the store entrance.
A broad view of the store interior with a customer at the counter, highlighting the open layout and service area.
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About Wentzville Root 66

Our Wentzville Root 66 store is located in the fastest growing city in the state of Missouri. Serving an increasing population of 45,000+, this 4,200 square foot location is among the best in Missouri. Wentzville is recognized as host of the annual St. Charles County Fair and the St. Louis Renaissance Festival. Wentzville is the location of the first Vietnam Veterans Memorial in the U.S.

Root 66 is honored to join the Wentzville community and offer local patients a wide variety of cannabis products including: cannabis flower, vapes, concentrates, edibles, beverages and more! We pride ourselves on our commitment to St. Charles County to offer the best experience and widest selection in town.

Find us at Root 66 Dispensary Wentzville, located at 1163 Wentzville Parkway, Wentzville, MO 63385. Click here for directions.

Our Store Manager’s

Top Picks

Meet Nate Oswald, the welcoming face behind our Wentzville location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Nate has some standout recommendations for you.

“Cannabis is a huge part of my day-to-day life. From using it to help me mentally manage everyday stresses, to physically feeling well during golf and other activities. I believe cannabis can be a huge benefit to a lot of different people with different needs. Nothing feels better than helping someone find a product that is not only enjoyable but also improves their overall life. I joined the Root 66 team in July of 2021, and look forward to helping customers learn about cannabis and expand my own knowledge in this ever-evolving industry.”

Nate Oswald

Favorite Consumption Method:

Concentrates

Must-Try Strain:

Orange 43 from Local & Ostara Rise Gummies

When did you start working for Root 66?

July 2021

Nate Oswald - Wentzville Store Manager. A cannabis leaf is in the bottom corner of the image.

Grow with Us

Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.

Google Reviews

Google
Rebel 420 profile picture
Rebel 420
Google star 1Google star 2Google star 3Google star 4Google star 5Trustindex verifies that the original source of the review is Google.
This was my first visit to this dispensary. Cedric helped me and he was a delight…the entire staff was very friendly and welcoming, including the guard. I also love that they have a pet food donation box. This will definitely be my favorite place.
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Josh Marshall profile picture
Josh Marshall
Google star 1Google star 2Google star 3Google star 4Google star 5Trustindex verifies that the original source of the review is Google.
Always good energy when I come in. Good stock, great prices.
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Jason Koch profile picture
Jason Koch
Google star 1Google star 2Google star 3Google star 4Google star 5Trustindex verifies that the original source of the review is Google.
Always super fast and friendly, great selection! Mimi was super helpful as well :)
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Jenn W profile picture
Jenn W
Google star 1Google star 2Google star 3Google star 4Google star 5Trustindex verifies that the original source of the review is Google.
My favorite store in the world! Employees are happy and helpful. I love the wide range of options and something for every price range.
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Charles Jackson profile picture
Charles Jackson
Google star 1Google star 2Google star 3Google star 4Google star 5Trustindex verifies that the original source of the review is Google.
Katie was awesome and super helpful! It's a great place!

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