ST. PETERS
3004 S. St. Peters Pkwy
St. Charles, MO 63303
Open 24/7
(walk-up window 12 AM - 7:59 AM)
































About St. Peters Root 66
Our Root 66 store in St. Peters was one of the first medical marijuana dispensaries to open to patients in St. Charles County. The City of St. Peters is a great place to live, work, play and visit, offering affordable, quality living with top-notch amenities and services. Money Magazine has recognized St. Peters multiple times as a Top 100 Best Places to Live in America.
Root 66 is proud to join the St. Peters community and offer local patients a wide variety of cannabis products including: cannabis flower, vapes, concentrates, edibles, beverages and more! We pride ourselves on our commitment to the community of St. Peters, to offer the best experience and widest selection in town.
Find us at Root 66 Dispensary St. Peters, located at 3004 S. St. Peters Pkwy, St. Charles, MO 63303. Click here for directions.
Our Store Manager’s
Top Picks
Meet Kayla Nettles, the welcoming face behind our St. Peters location. With years of experience in the cannabis industry and a deep passion for helping our customers discover the perfect products, Kayla has some standout recommendations for you.
“Cannabis has become a way to relieve my chronic migraines and body aches with a more natural approach. Increasing my knowledge of the medicinal benefits of cannabis and sharing that knowledge with patients has become a true passion. It's time for the stigma around cannabis to change and that change starts here, with us!”
Kayla Nettles
Favorite Consumption Method:
Flower and vape
Must-Try Strain:
Illicit Animal Star Cookies and Ostara Balance Gummies
When did you start working for Root 66?
October 2023

Grow with Us
Cultivate Your Career in Cannabis with Root 66. Join our passionate team and be part of the journey that’s shaping the future of the cannabis industry.
Google Reviews
Rebel 420Trustindex verifies that the original source of the review is Google. This was my first visit to this dispensary. Cedric helped me and he was a delight…the entire staff was very friendly and welcoming, including the guard. I also love that they have a pet food donation box. This will definitely be my favorite place. Josh MarshallTrustindex verifies that the original source of the review is Google. Always good energy when I come in. Good stock, great prices. Jason KochTrustindex verifies that the original source of the review is Google. Always super fast and friendly, great selection! Mimi was super helpful as well :) Jenn WTrustindex verifies that the original source of the review is Google. My favorite store in the world! Employees are happy and helpful. I love the wide range of options and something for every price range. Charles JacksonTrustindex verifies that the original source of the review is Google. Katie was awesome and super helpful! It's a great place!